CAN_328

origin: Mechanistic analysis of allosteric and non-allosteric effects arisingPm nanobody binding to two epitopes of the dihyrofolate reductase of Escherichia coli.
author: Oyen, D., Wechselberger, R., Srinivasan, V., Steyaert, J., Barlow, J.N.
patent: no
publication_number: not known
patent_application_number: not known
CDR1_seq: IFSVYKMT(predict)
CDR1_length: 8
CDR2_seq: LITTNNNTM(predict)
CDR2_length: 9
CDR3_seq: NRGLAGPAY(predict)
CDR3_lentgh: 9
protein_seq: QVQLQESGGGLVQAGGSLRLSCKASGIIFSVYKMTWYRQAPGKERELVALITTNNNTMTVDSVKGRFTISRDNVQNTVYLEMNNLKPEDTAVYYCNANRGLAGPAYWGQGTQVTVSSHHHHHH
DNA_seq: not known
PubMed_ID: 23911607
PDB_ID: 4EIG
PDB_deposition_date: 2012-04-05
PDB_released_date: 2013-04-24
resolution: 2.5Å
source_organism: Lama glama
experiment_method: llama immunization,library construction,screen,express
antigen: the dihyrofolate reductase of Escherichia coli
antigen_chain: not known
antigen_source: Escherichia coli
antigen_seq: MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR
epitope: not known
IEDB_ID: not known
epitope_reference: not known
function: Mechanistic analysis of allosteric and non-allosteric effects
validationORprediction: Experiment Validation
bacteria_family: Escherichia coli
publication: Biochim Biophys Acta. 2013 Oct;1834(10):2147-57. doi: 10.1016/j.bbapap.2013.07.010. Epub 2013 Jul 31.